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PHLPP1 (18q21) + Copy Control FISH Probe
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Cat.No.
FON-129
Description
This probe is designed to detect copy number variations in the 18q21 region on chromosome 18. The PHLPP1 gene encodes a protein phosphatase that regulates cell growth and survival pathways. It has been stated that PHLPP1 gene aberrations contribute to the deregulation of the AKT and PKC cell growth and survival pathway in colorectal cancer. Apart from that, PHLPP1 may serve as a therapeutic target that inhibits prostate cancer progression through mTORC2 antagonism. Preliminary studies also suggest a correlation between PHLPP1 and PTEN gene aberrations related to prostate cancer metastasis.
Size
10 Tests
Label
Red/Green
Locus
18q21/SE18
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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