PAX7 Breakapart Probe

FONC-097

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. One of the primary histological subtypes is the alveolar RMS (ARMS). The majority (80%) of ARMS are associated with the t(2;13)(q35;q14) translocation and less commonly with t(1;13)(p36;q14), leading to the fusion of transcription factor FHKR or FOXO1 to the transcription factors PAX3 and PAX7 respectively.In cases of ARMS which is negative for FKHR translocation, two variant PAX3 translocation associated fusion transcripts (PAX3-AFX and PAX3-NCOA1) could be present.

5 Tests, 10 Tests

Red/Green

Human

1p36/13q14

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade

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