Melanoma FISH Probe Kit is designed to detect copy number of the RREB1 (6p25), MYB (6q23), CCND1 (11q13) genes and of centromere 6 via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin embedded human skin tissue specimens. The Melanoma FISH Probe Kit is indicated as an aid in the diagnosis of melanoma in skin biopsy specimens.
The RREB1 (6p25) Probe is labeled with SpectrumRed and covers an approximately 638 kb region that contains the entire RREB1 gene. The MYB (6q23) probe is labeled with SpectrumGold and covers an approximately 740 kb region that contains the entire MYB gene. The CCND1 (11q13) probe is labeled with SpectrumGreen and covers an approximately 378 kb region that contains the entire CCND1 gene. The CEP 6 probe, labeled with SpectrumAqua, hybridizes to the alpha satellite DNA located at the centromere of chromosome 6 (6p11.1-q11.1).
For Research Use Only. Not for use in diagnostic procedures.
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