Extranodal marginal zone B-cell lymphoma (MZBCL) of the MALT (Mucosa-Associated Lymphoid Tissue) type is characterised by two main translocations involving MALT1; t(11;18)(q21;q21) and t(14;18)(q32;q21). The t(11;18) API2/BIRC3/MALT1 translocation is present in 30% of cases of MALT lymphoma, the fusion protein induces NF-κB resulting in transcription activation. Eighteen percent of MALT lymphomas harbour the t(14;18) MALT1/IGH translocation. A break or split probe for MALT (18q21) is best used to analyze translocation of the MALT gene at 18q21.
For Research Use Only. Not for use in diagnostic procedures.
Store at minus 20 centigrade
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.