Mesenchymal stem cells (MSC) are a well-characterized population of adult stem cells. MSC have the potential to develop into mature cells that produce fat, cartilage, bone, tendons, and muscle. This property, in combination with MSC's developmental plasticity, has generated tremendous interest in the potential use of MSC to replace damaged tissues. MSC isolated from Wharton's jelly of umbilical cords were induced to transform into neurons and glia in vitro through stepwise culturing in neuron-conditioned medium, sonic hedgehog, and FGF-8 ; to cardiomyocytes by treating then with 5-azacytidine or by culturing them in cardiomyocytes-conditioned medium; and to adipogenic and osteogenic lineage. They express matrix receptors CD44 and CD10^5, but not hematopoietic lineage marker CD34, and a significant quantity of mesenchymal stem cell markers SH2 and SH3.HUMSC from Bioarray Research Laboratories are isolated from Wharton's jelly of umbilical cords. HUMSC are cryopreserved at passage one culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HUMSC are characterized by immunofluorescent method with antibodies to CD73, CD90 and CD105. HUMSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HUMSC are guaranteed to further culture at the conditions provided by Bioarray Research Laboratories.
Storage and Shipping
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture is needed for experiments.
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