HEC-1-B

HEC-1-B is a cell line derived from human endometrial adenocarcinoma. It was originally isolated from a patient with endometrial cancer and exhibits an endometrial carcinoma moderately differentiated phenotype. These cells have been used extensively as a model system to study endometrial cancer biology in vitro including tumor progression and response to therapeutics.

In culture, HEC-1-B cells form an adherent epithelial like monolayer with polygonal/cobblestone cell morphology. HEC-1-B cell growth has been shown to be relatively stable when compared to other endometrial cancer cell lines with fewer variations and greater reproducibility between experiments. These cells express epithelial markers and demonstrate dysregulation of pathways associated with cell cycle progression, apoptosis and hormone receptor responsiveness. Typically, HEC-1-B cells are estrogen and progesterone receptor-negative and have been used to study hormone independent growth of endometrial tumors. HEC-1-B cells have been used in the study of signal transduction, invasion and metabolism in endometrial carcinoma. HEC-1-B cells have been used as a model system for testing the efficacy of chemotherapeutics and targeted anticancer agents.