FOXO2 Break Probe Kit

Specification
Recommended Products

Cat.No.

FONC-058

Description

Chromosomal rearrangements involving the FOXO1 gene on chromosome 13q14 are associated with alveolar rhabdomyosarcoma (ARMS). Identification of RMS is a diagnostic dilemma for pathologists, requiring a significant amount of rule out testing for this and other soft-tissue cancers. ARMS is characterized by two consistent chromosomal translocations, the common t(2;13)(q35.2;q14) and the variant t(1;13)(p36;q14) resulting in the formation of PAX3-FOXO1 and PAX7-FOXO1fusion genes respectively (~80% of cases of ARMS). Hybridization with the Vysis LSI FOXO1 (13q14) Dual Color, Break Apart Rearrangement Probe will identify a chromosomal rearrangement at the FOXO1 gene but not a specific gene-fusion partner. This Probe consists of a mixture of two FISH DNA probes. The first probe, a 720 kb probe labeled in SpectrumGreen lies proximal to the FOXO1 gene. The second probe labeled in SpectrumOrange extends distally from the FOXO1 gene and is approximately 650 kb in length.

Size

20 Tests

Label

Red/Green

Locus

13q14

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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