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CHOP Break Probe
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Cat.No.
FONC-028
Description
Myxoid liposarcoma is the most common subtype of liposarcoma. The TLS-CHOP t(12;16)(q13;p11) fusion gene is now well established and present in at least 95% of MLS. In rare cases a EWS-CHOP t(12;22)(q13;q12) translocation has been described. The transcription factor gene, CHOP (DDIT3) is a negative regulator of adipocyte differentiation so the TLS-CHOP protein interferes with adipocyte differentiation and favours proliferation over terminal differentiation.
A break or split probe for CHOP is best used to analyze translocation of the CHOP (12q13) gene.
Size
10 Tests
Label
Red/Green
Locus
12q13
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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