CEP 12 Probe is a SpectrumOrange labeled probe specific for the alpha satellite (centromeric) region, 12p11.1-q11.
The CEP 12 Probe may be used as an adjunct to standard karotyping to identify and enumerate chromosome 12 in nuclei of cells obtained from peripheral blood lymphocytes with B-cell chronic lymphocytic leukemia (B-CLL). In multi-site l trials, the CEP 12 analysis of interphase nuclei was 100% sensitive and 91% specific as compared to traditional cytogenetic analysis when adequate metaphase preparations could be produced. Results are available within 3 hours or less. Trisomy 12 is the most commonly reported chromosome aberration in CLL. Chromosomal aberrations, determined by cytogenetic analysis are present in up to 55% of all B-CLL cases.
12p11.1-q11 Alpha Satellite DNA
For Research Use Only. Not for use in diagnostic procedures.
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