The BIRC3/MALT1 DF FISH Probe Kit is intended to detect the t(11;18)(q21;q21) reciprocal translocation involving the BIRC3 (also know as API2) and MALT1 gene regions using the fluorescence in situ hybridization (FISH) technique.
The t(11;18)(q21;q21) translocation is the most common chromosomal translocation found in mucosa-associated lymphoid tissue (MALT) lymphoma1 and is the most common in gastric MALT lymphoma. The t(11;18)(q21;q21) translocation is associated with failure to respond to Helicobacter pylori eradication and an aggressive disorder. The BIRC3/MALT1 Dual Color Dual Fusion probe has been used to identify the t(11;18)(q21;q21) translocation in published reports.
For Research Use Only. Not for use in diagnostic procedures.
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