The AML/ETO t(8;21)(q21;q22) specific DNA Probe is optimized to detect the reciprocal translocation t(8;21) in a Dual-Color, Dual-Fusion.
AML1 is fused with ETO in the t(8;21)(q21;q22) translocation.Overall, 7% of AML cases demonstrate the abnormality. Three-way variants of this rearrangement and the t(3;21) (AML1/EVI1) show that juxtaposition of AML1 to the derivative chromosome is consistent and therefore the critical rearrangement.
For Research Use Only. Not for use in diagnostic procedures.
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