The 9q34 Probe is intended to detect deletion of the Vysis 9q34 probe target region using the fluorescence in situ hybridization (FISH) technique.
Chronic myelogenous leukemia (CML) has a characteristic t(9;22) (q34;q11.2) that results in fusion of the BCR and ABL1 genes. Among a small sub set of samples, there is an associated deletion of a region of 9q34 proximal to the ABL1 breakpoint which includes the arginosuccinate synthetase gene (ASS1). In two different studies of CML samples, the 9q34 SpectrumAqua probe has been shown to detect deletions of this 9q34 region.
For Research Use Only. Not for use in diagnostic procedures.
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