The TRA/D Break Apart FISH Probe Kit is intended to detect chromosomal rearrangements involving the T-cell receptor alpha/delta locus at chromosome 14q11.2 using the fluorescence in situ hybridization (FISH) technique.
Acute Lymphoblastic Leukemia (ALL) accounts for 25% of all pediatric cancer and 15% of pediatric ALL is of T-Cell lineage (T-ALL).1 T-ALL andT-Cell Lymphoblastic Lymphoma (T-LBL) are described by the World Health Organization classification as similar entities that are discerned by the relative percentage of bone marrow infiltration.2 The Vysis TRA/Dual Color Break Apart Rearrangement Probe was used in a study to detect TCR alpha/delta rearrangements in 22 randomly selected Children's Oncolgy Group.
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