Deregulation of normal transcription is a feature of all types of acute leukaemia. In T-ALL, this is brought about by altered expression of normal transcription factor proteins.
T-ALL is a feature of between 12 to 15% of childhood ALL. In about 30% of these cases, chromosomal translocations involving the T-cell receptor genes TCRA, TCRB, TCRG and TCRD have been described.
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