Deregulation of normal transcription is a feature of all acute leukaemias. In T-cell neoplasms, this is brought about by altered expression of normal transcription factor proteins. This is the result of chromosomal translocations resulting in the promoter and enhancer elements of the T-cell receptor genes TCRA, TCRB, TCRG and TCRD being brought into close proximity with one of these T-cell receptor genes.
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