PML/RARA Dual Color, Dual Fusion Translocation Probe

FHPC-089

The reciprocal and balanced t(15;17), involving the PML (promyelocytic leukemia) gene on chromosome 15q22 and the RARA (retinoic acid receptor alpha) gene on chromosome 17q12.1 is a characteristic molecular feature of certain types of leukemia. Two gene fusion products result from this translocation, each of which encodes a functional chimeric protein: PML/RARA and RARA/PML. The breakpoints in the 15q22 region of chromosome 15 occur within a 13 kb region of the PML gene that contains three breakpoint cluster regions (bcr): bcr 3 extends from intron 3 through the 5' end of intron 4, bcr 2 extends from exon 5 to exon 6, and bcr 1 extends from intron 6 into exon 7. Break frequency is highest in bcr 1, followed by bcr 3 and bcr 2. The breakpoints on chromosome 17 occur within the approximately 17 kb intron 2 of the RARA gene.

20 Tests

Red/Green

Human

15q22/17q21.1

For Research Use Only. Not for use in diagnostic procedures.

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