The ETV6 fluorescence in situ hybridization (FISH) probe set is intended to detect rearrangements of the ETV6 gene locus in the chromosome 12p13 region. Rearrangements of the short arm of chromosome 12 are frequently recurring abnormalities found in a variety of hematologic malignancies of both myelocytic and lymphoid origin. They include balanced and unbalanced translocations which prevalently involve band 12p13.
The ETV6 (TEL) gene is the most common target found to be rearranged with more than 40 chromosome bands. ETV6-RUNX1 (AML1) gene fusion resulting from a t(12;21) has been characterized as the most common genetic lesion in pediatric acute lymphoblastic leukemia (ALL) and is associated with a favorable outcome. The ETV6 Dual Color Break Apart Rearrangement Probe has successfully been used in detecing ETV6 (TEL) gene.
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