Description
The ETV6 fluorescence in situ hybridization (FISH) probe set is intended to detect rearrangements of the ETV6 gene locus in the chromosome 12p13 region. Rearrangements of the short arm of chromosome 12 are frequently recurring abnormalities found in a variety of hematologic malignancies of both myelocytic and lymphoid origin. They include balanced and unbalanced translocations which prevalently involve band 12p13.
The ETV6 (TEL) gene is the most common target found to be rearranged with more than 40 chromosome bands. ETV6-RUNX1 (AML1) gene fusion resulting from a t(12;21) has been characterized as the most common genetic lesion in pediatric acute lymphoblastic leukemia (ALL) and is associated with a favorable outcome. The ETV6 Dual Color Break Apart Rearrangement Probe has successfully been used in detecing ETV6 (TEL) gene.
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no.
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