CKS1B/CDKN2C(P18) Amplification/Deletion Probe

FHPC-031

Structural abnormalities of chromosome 1 are frequently detected in multiple myeloma, and have been correlated with more advanced disorder. Amplification of 1q21 (CKS1B) is one of the most recurrent chromosomal aberrations in multiple myeloma. Over-expression of the CKS1B gene up-regulates cell cycle progression resulting in a more proliferative disorder. CDKN2C (P18) is a tumour suppressor gene responsible for inducing apoptotic cell death and DNA fragmentation, deletion of the gene is associated with a more proliferative disorder. Although P18 deletions have been reported to be rare in human malignancy, cytogenetic analysis has shown abnormalities in 16% of human multiple myeloma.

5 Tests, 10 Tests

Red/Green

Human

1q21/17p13.1

For Research Use Only. Not for use in diagnostic procedures.

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