Structural abnormalities of chromosome 1 are frequently detected in multiple myeloma, and have been correlated with more advanced disorder. Amplification of 1q21 (CKS1B) is one of the most recurrent chromosomal aberrations in multiple myeloma. Over-expression of the CKS1B gene up-regulates cell cycle progression resulting in a more proliferative disorder. CDKN2C (P18) is a tumour suppressor gene responsible for inducing apoptotic cell death and DNA fragmentation, deletion of the gene is associated with a more proliferative disorder. Although P18 deletions have been reported to be rare in human malignancy, cytogenetic analysis has shown abnormalities in 16% of human multiple myeloma.
For Research Use Only. Not for use in diagnostic procedures.
Store at minus 20 centigrade
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.