CEP 8 is a SpectrumOrange labeled probe specific for the alpha satellite (centromeric) region, 8p11.1-q11.1.
The CEP 8 Probe may be used as an adjunct to standard karotyping to identify and enumerate chromosome 8 in cells obtained from bone marrow. In multi-site trials, the CEP 8 Probe for interphase analysis was 96% sensitive and 98% specific as compared to traditional cytogenetic analysis. A close association has been made between trisomy 8 and both myeloid blast crisis and basophilia. Trisomy 8 is a prevalent genetic aberration in several specific disorders: Chronic Myelogenous Leukemia (CML), Acute Myeloid Leukemia (AML), Myeloproliferative disorders (MPD), Myelodysplastic Syndrome (MDS), Other hematologic disorders not specified (HDNOS).
8p11.1-q11.1 Alpha Satellite DNA
For Research Use Only. Not for use in diagnostic procedures.
Store at minus 20 centigrade
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