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Immortalized Rat Schwann Cells (IFRS1)
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Cat.No.
CSC-I9218L
Description
Schwann cells are valuable tools for diabetic neuropathy pathogenesis involving glycation, reduced regenerative capability, oxidative stress, and other neurodegenerative diseases. The Immortalized Rat Schwann Cells express transcription factors (Krox20, Oct6, and SOX10), myelin proteins (P0, PMP22, and MAG), neurotrophic factors (NGF, GDNF, and CNTF), cell adhesion molecules (L1, NCAM, and N-Cadherin), and neurotrophin receptors (truncated TrkB, and TrkC), all of which points to distinct Schwann cell phenotype. Other glial markers such as S100, p75NTR, vimentin, GFAP, and laminin are also exhibited. These cells are unique in that they retain features of mature Schwann cells with the ability to myelinate neurites in co-culture with rat DRG neurons, thus providing a valuable tool to study neuron-Schwann cell interactions.
Source
Brain
Culture Properties
Adherent
Morphology
Spindle-shaped
Immortalization Method
Spontaneous Immortalization
Applications
For Research Use Only
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Note: Never can cells be kept at -20 °C.
Note: Never can cells be kept at -20 °C.
Shipping
Dry Ice.
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CSC-C1795 Rat Schwann Cells
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CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Quality Control
Immunoreactivity to cell markers
BioSafety Level
II
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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