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Immortalized Mouse Dopaminergic Neuronal Cells (MN9D)
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Cat.No.
CSC-I2295Z
Description
Immortalized Mouse Dopaminergic Neuronal Cell line (MN9D) was generated by fusion between rostral mesencephalic neurons from a 14-day-old C57BL/6J mouse embryo and N18TG2 neuroblastoma cells, a sympathetic nervous system cancer of A/Jax background. MN9D cells produce dopamine (DA) and express tyrosine hydroxylase (TH) as well as aromatic amino acid decarboxylase (AADC). MN9D cells readily aggregate with one another or other embryonic brain cells and can be transfected using calcium phosphate precipitation or Lipofectamine. Undifferentiated or differentiated MN9D cells are extensively used to model dopaminergic neurons and to test mechanisms and potential therapeutics relevant to the loss of DA neurons in Parkinson's disease. Differentiated with butyric acid or glial cell line-derived neurotrophic factor (GDNF) followed by butyric acid, MN9D cells only partially recapitulate the electrophysiological properties of midbrain DA neurons. Optimizing MN9D differentiation further using one or a combination of growth or other factors may yield an improved model system for Parkinson's disease studies in vitro.
Culture Properties
Adherent
Morphology
Polygonal
Applications
For Research Use Only
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
CSC-I9001L
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