ESR1 FISH Probe

FONC-128

ESR1 FISH Probe is specifically designed to detect amplifications and deletions of the ESR1 gene. This probe is equipped with vibrant orange labeling for enhanced visualization, and we offer customization options to meet your specific research requirements.

ESR1 (Estrogen Receptor 1) encodes a nuclear hormone receptor that is critical for mediating the effects of estrogen in various tissues, particularly in breast tissue. It plays a significant role in regulating gene expression involved in cell growth, differentiation, and apoptosis. Abnormalities in ESR1, including amplifications and mutations, are commonly associated with breast cancer, particularly in hormone receptor-positive subtypes. These alterations can lead to resistance to endocrine therapies, making ESR1 a key target for both diagnosis and treatment.

Clinical Relevance: The detection of ESR1 amplifications and deletions is crucial for understanding the molecular landscape of breast cancer. Identifying these genetic alterations can aid in prognosis and guide treatment decisions, particularly in determining the appropriateness of hormone therapies. Furthermore, understanding ESR1 status can help predict responses to targeted therapies, such as aromatase inhibitors and selective estrogen receptor modulators (SERMs).

Our ESR1 FISH Probe is an essential tool for researchers dedicated to advancing the understanding of estrogen signaling in cancer and improving patient management through personalized treatment strategies.

10 Tests; 20 Tests

Orange/Green/Aqua

Human

6q25.1

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade in the dark

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.