The IGH (14q32) Break Probe is designed to detect translocations involving the IGH gene region at 14q32 in a Dual-Color, split assay.
In ALL, IGH is most notably involved in rearrangements involving the cMYC oncogene as a result of the t(8;14) translocation. However, less common rearrangements of the IGH gene are most often seen in T-ALL and also in B-ALL.
There are a number of stereotypical translocations involved in each of the two disorders and more are being described regularly.
In CLL,cytogenetically abnormal CLL has a detectable 14q marker chromosome. The markers are derived from reciprocal translocations involving a number of fusion partners from different chromosomes that fuse with the IGH gene at 14q32. Involvement of chromosomes 1, 2, 5, 6, 7, 8, 9, 11, 12, 13, 14, 17, 18, 19 and 22 have been described and the two most common translocations are IGH/BCL2 involving the t(14;18) translocation and IGH/CCND1 involving the t(11;14) translocation.
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