Lung Tumor Cells
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, primarily categorized into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). These tumors are characterized by significant genetic diversity, involving key driver mutations such as EGFR, KRAS, and ALK rearrangements.
Our lung tumor cell line collection offers a comprehensive range of in vitro models, including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, as well as aggressive SCLC models. These cell lines are essential tools for studying lung cancer pathogenesis, identifying novel biomarkers, and evaluating the efficacy of targeted therapies and immunotherapies.
Comprehensive Genotyped Validated High-Quality
Key Features & Expertise
Our lung tumor cell lines are distinguished by their molecular depth and experimental versatility:
Extensive Pathological Diversity
- Full coverage of NSCLC subtypes: Adenocarcinoma, Squamous Cell, and Large Cell Carcinoma
- Highly aggressive SCLC models characterized by rapid growth and neuroendocrine features
- Rare lung tumor models and drug-resistant variants for specialized oncology research
Defined Molecular & Genetic Profiles
- Characterized driver mutations including EGFR (L858R, T790M), KRAS (G12C/D/V), and ALK/ROS1 fusions
- Profiles for tumor suppressors such as TP53, PTEN, and STK11
- Data on PD-L1 expression levels to support immunotherapy and checkpoint inhibitor research
Stringent Quality Assurance
- STR authentication for every cell line to ensure genetic integrity
- Rigorous screening for Mycoplasma, bacteria, and viral contaminants
- Optimized protocols for 2D culture, 3D spheroids, and xenograft applications
FAQ
What are the main differences between NSCLC and SCLC cell lines?
NSCLC cell lines (85% of lung cancers) typically grow slower and represent adenocarcinoma or squamous cell carcinoma. SCLC cell lines are more aggressive, show rapid doubling times, and often exhibit neuroendocrine markers and a higher propensity for early metastasis.
Do you provide cell lines with specific EGFR or KRAS mutations?
Yes. Our collection includes cell lines with specific mutations such as EGFR exon 19 deletions, L858R point mutations, and KRAS G12C, which are critical for studying sensitivity or resistance to TKIs (Tyrosine Kinase Inhibitors).
Can these cell lines be used for PD-L1 and immunotherapy studies?
Absolutely. Many of our lung tumor cell lines have documented PD-L1 expression levels, making them ideal for co-culture assays with T-cells or testing anti-PD-1/PD-L1 therapeutic agents.
How do I choose between an adenocarcinoma and a squamous cell carcinoma model?
The choice depends on your research focus. Adenocarcinoma models are often preferred for studying mucus-secreting epithelial pathways and EGFR/ALK targeted therapies, while squamous cell models are better for investigating smoking-related oncogenesis and FGFR-related signaling.
Are the cell lines suitable for 3D culture or organoid formation?
Yes, many of our lung tumor cell lines, are validated for 3D culture and high-throughput screening. They can form stable spheroids that better mimic the in vivo tumor microenvironment.
Filters Clear all filters
Species
- Cat (1)
- Human (989)
- Mouse (5)
- Rat (1)
Source
- Abdomen Metastasis (2)
- Adrenal Gland (7)
- Adrenal Gland Metastasis (2)
- Ascites (23)
- Ascites Metastasis (32)
- Bile Duct (3)
- Bladder (12)
- Blood (120)
- Bone (21)
- Bone Marrow (43)
- Bone Marrow Metastasis (18)
- Bone Metastasis (6)
- Brain (31)
- Brain Metastasis (6)
- Breast (8)
- Bronchus (1)
- Cecum (3)
- Cerebrospinal Fluid (1)
- Cerebrospinal Fluid Metastasis (1)
- Cervix (32)
- Colon (83)
- Cornea (3)
- Cutaneous Metastasis (1)
- Dermis (1)
- Duodenum (1)
- Endometrium (17)
- Esophagus (44)
- Eye (12)
- Eye Socket (5)
- Fetus (1)
- Foreskin (4)
- Gallbladder (1)
- Gingiva (2)
- Globe (2)
- Groin (1)
- Hypodermis Metastasis (5)
- Intestine (84)
- kidney (1)
- Kidney (9)
- Liver (13)
- Liver Metastasis (17)
- Lung (42)
- Lung Metastasis (8)
- Lymph Node (5)
- Lymph Node Metastasis (56)
- Muscle (4)
- Muscle Metastasis (2)
- Nose (2)
- Omentum Metastasis (2)
- Oral Cavity (10)
- Ovary (13)
- Ovary Metastasis (2)
- Pancreas (10)
- Pelvic Wall Metastasis (1)
- Pelvis (1)
- Perianal Space Metastasis (1)
- Pericardial Effusion (1)
- Pericardial Effusion Metastasis (1)
- Perineus (1)
- Peripheral Blood (119)
- Peritoneal Effusion (2)
- Peritoneum (1)
- Peritoneum Metastasis (1)
- Pharynx (3)
- Pleural Effusion (54)
- Pleural Effusion Metastasis (44)
- Prostate (4)
- Rectum (13)
- Renal Pelvis (1)
- Retroperitoneal Space (2)
- Salivary Gland (2)
- Skeletal Muscle (1)
- Skin (22)
- Skin Metastasis (3)
- Small Intestine (1)
- Small Intestine Metastasis (1)
- Soft Tissue Metastasis (1)
- Stomach (4)
- Testis (9)
- Thoracic Cavity Metastasis (6)
- Thyroid Gland (15)
- Thyroid Gland Metastasis (1)
- Tongue (5)
- Umbilical Cord (1)
- Umbilical Cord Blood (1)
- Urachus (1)
- Ureter (1)
- Uterus (53)
- Uvea (2)
- Vagina (2)
- Vulva (1)
Disease
- Acute Biphenotypic Leukemia (1)
- Acute Erythroid Leukemia (4)
- Acute Megakaryoblastic Leukemia (4)
- Acute Monocytic Leukemia (9)
- Acute Myeloid Leukemia (25)
- Acute Promyelocytic Leukemia (2)
- Adrenal Gland Neuroblastoma (11)
- Adult B Acute Lymphoblastic leukemia (1)
- Adult B Acute Lymphoblastic Leukemia (6)
- Adult T Acute Lymphoblastic Leukemia (6)
- Adult T Lymphoblastic Lymphoma (2)
- Adult T-Cell Leukemia/Lymphoma (1)
- Alveolar Rhabdomyosarcoma (4)
- Alveolar Ridge Squamous Cell Carcinoma (1)
- Amelanotic Melanoma (3)
- Ampulla of Vater Adenocarcinoma (1)
- Ampulla of Vater Adenosquamous Carcinoma (3)
- Anaplastic Astrocytoma (3)
- Anaplastic Large Cell Lymphoma (7)
- Askin Tumor (1)
- Astrocytoma (5)
- B Acute Lymphoblastic Leukemia (2)
- B-Cell Non-Hodgkin Lymphoma (5)
- Bare Lymphocyte Syndrome Type 2 (1)
- Barrett Adenocarcinoma (2)
- Benign Prostatic Hyperplasia (1)
- Bladder Carcinoma (12)
- Bladder Squamous Cell Carcinoma (1)
- Breast Adenocarcinoma (1)
- Breast Carcinoma (9)
- Breast Ductal Carcinoma (2)
- Burkitt Lymphoma (17)
- Canavan Disease (1)
- Cecum Adenocarcinoma (3)
- Central Nervous System Lymphoma (2)
- Cervical Adenocarcinoma (2)
- Cervical Adenosquamous Carcinoma (2)
- Cervical Small Cell Carcinoma (1)
- Cervical Squamous Cell Carcinoma (2)
- Childhood B Acute Lymphoblastic Leukemia (13)
- Childhood T Acute Lymphoblastic Leukemia (16)
- Childhood T Lymphoblastic Lymphoma (1)
- Cholangiocarcinoma (2)
- Chronic Eosinophilic Leukemia (1)
- Chronic Lymphocytic Leukemia (2)
- Chronic Myeloid Leukemia (23)
- Clear Cell Renal Cell Carcinoma (2)
- Colon Adenocarcinoma (53)
- Colon Carcinoma (33)
- Colorectal Adenocarcinoma (1)
- Colorectal Carcinoma (1)
- Congenital Pure Red Cell Aplasia (1)
- Cutaneous Melanoma (10)
- Dedifferentiated Chondrosarcoma (1)
- Desmoplastic Melanoma (1)
- Diffuse Large B-Cell Lymphoma (28)
- Down Syndrome (2)
- EBV-Related Burkitt Lymphoma (12)
- Embryonal Carcinoma (3)
- Embryonal Rhabdomyosarcoma (3)
- Endometrial Adenocarcinoma (13)
- Endometrial Adenosquamous Carcinoma (2)
- Endometrial Carcinoma (2)
- Endometrioid Stromal Sarcoma (1)
- Epithelioid Hemangioendothelioma (1)
- Epithelioid Sarcoma (3)
- Esophageal Adenocarcinoma (6)
- Esophageal Squamous Cell Carcinoma (41)
- Essential Thrombocythemia (1)
- Ewing Sarcoma (2)
- Extraskeletal Myxoid Chondrosarcoma (1)
- Fanconi Anemia (1)
- Fibrosarcoma (1)
- Follicular Lymphoma (2)
- Gallbladder Carcinoma (2)
- Gallbladder Undifferentiated Carcinoma (2)
- Gastric Adenocarcinoma (6)
- Gastric Adenosquamous Carcinoma (1)
- Gastric Carcinoma (5)
- Gastric Choriocarcinoma (1)
- Gastric Fundus Carcinoma (1)
- Gastric Signet Ring Cell Adenocarcinoma (1)
- Gastric Small Cell Carcinoma (2)
- Gastric Tubular Adenocarcinoma (5)
- Gastroesophageal Junction Adenocarcinoma (1)
- Gestational Choriocarcinoma (1)
- Gingival Squamous Cell Carcinoma (2)
- Glioblastoma (18)
- Gliosarcoma (1)
- Hairy Cell Leukemia (1)
- Hepatoblastoma (2)
- Hepatocellular Carcinoma (6)
- Hepatosplenic T-Cell Lymphoma (2)
- Hereditary Thyroid Gland Medullary Carcinoma (1)
- High Grade B-Cell Lymphoma (1)
- High Grade Ovarian Serous Adenocarcinoma (8)
- Hodgkin Lymphoma (9)
- Hypopharyngeal Squamous Cell Carcinoma (2)
- Infectious Mononucleosis (1)
- Intrahepatic Cholangiocarcinoma (6)
- Invasive Breast Carcinoma of No Special Type (12)
- Kidney Neoplasm (1)
- Kidney Rhabdoid Tumor (1)
- Krukenberg Tumor (1)
- Liposarcoma (1)
- Lung Adenocarcinoma (17)
- Lung Giant Cell Carcinoma (8)
- Lung Large Cell Carcinoma (9)
- Lung Mucoepidermoid Carcinoma (1)
- Lung Non-Small Cell Carcinoma (2)
- Lung Small Cell Carcinoma (25)
- Lung Squamous Cell Carcinoma (9)
- Lymphoblastic Lymphoma (1)
- Malignant Peripheral Nerve Sheath Tumor (1)
- Mantle Cell Lymphoma (5)
- Mature Gastric Teratoma (1)
- Maxillary Sinus Squamous Cell Carcinoma (1)
- Medulloblastoma (3)
- Melanoma (24)
- Meningioma (2)
- Minimally Invasive Lung Adenocarcinoma (1)
- Monophasic Synovial Sarcoma (1)
- Mouse Intestinal Tract Neuroendocrine Adenoma (1)
- Mouse Mammary Gland Malignant Neoplasm (2)
- Mouse Plasmacytoma (1)
- Mycosis Fungoides (1)
- Myelodysplastic Syndrome (1)
- Myxofibrosarcoma (1)
- Natural Killer Cell Lymphoblastic Leukemia/Lymphoma (2)
- Neuroblastoma (26)
- Oral Cavity Squamous Cell Carcinoma (15)
- Osteoid Osteoma (1)
- Osteosarcoma (15)
- Ovarian Carcinoma (1)
- Ovarian Clear Cell Adenocarcinoma (1)
- Ovarian Endometrioid Adenocarcinoma (4)
- Ovarian Granulosa Cell Tumor (1)
- Ovarian Mucinous Adenocarcinoma (2)
- Ovarian Serous Adenocarcinoma (2)
- Ovarian Serous Cystadenocarcinoma (2)
- Ovarian Small Cell Carcinoma (1)
- Pancreatic Adenocarcinoma (13)
- Pancreatic Carcinoma (5)
- Pancreatic Ductal Adenocarcinoma (12)
- Papillomavirus-Independent Cervical Squamous Cell Carcinoma (1)
- Papillomavirus-Related Cervical Adenocarcinoma (7)
- Papillomavirus-Related Cervical Squamous Cell Carcinoma (4)
- Papillomavirus-Related Endocervical Adenocarcinoma (16)
- Paroxysmal Nocturnal Hemoglobinuria (3)
- Pharyngeal Squamous Cell Carcinoma (1)
- Plasma Cell Myeloma (15)
- Pleural Epithelioid Mesothelioma (5)
- Pleural Sarcomatoid Mesothelioma (2)
- Poorly Differentiated Thyroid Gland Carcinoma (1)
- Primary Cutaneous T-Cell Non-Hodgkin Lymphoma (1)
- Primary Effusion Lymphoma (7)
- Primitive Neuroectodermal Tumor (1)
- Prostate carcinoma (1)
- Prostate Carcinoma (9)
- Rectal Adenocarcinoma (13)
- Rectosigmoid Adenocarcinoma (1)
- Recurrent Bladder Carcinoma (1)
- Renal Cell Carcinoma (7)
- Renal Pelvis Urothelial Carcinoma (1)
- Retinoblastoma (11)
- Sacral Chordoma (1)
- Sacrococcygeal Teratoma (1)
- Salivary Gland Squamous Cell Carcinoma (1)
- Sezary Syndrome (1)
- Shwachman-Diamond Syndrome (1)
- Skin Squamous Cell Carcinoma (2)
- Splenic Marginal Zone Lymphoma (1)
- Testicular Embryonal Carcinoma (8)
- Testicular Teratoma (2)
- Testicular Yolk Sac Tumor (1)
- Thyroid Gland Anaplastic Carcinoma (10)
- Thyroid Gland Follicular Carcinoma (4)
- Thyroid Gland Papillary Carcinoma (3)
- Thyroid Gland Sarcoma (1)
- Thyroid Gland Squamous Cell Carcinoma (2)
- Tongue Adenosquamous Carcinoma (1)
- Tongue Squamous Cell Carcinoma (6)
- Type I Endometrial Adenocarcinoma (1)
- Ureter Urothelial Carcinoma (1)
- Uterine Carcinosarcoma (2)
- Uterine Corpus Leiomyosarcoma (1)
- Uterine Corpus Sarcoma (2)
- Uveal Melanoma (2)
- Vaginal Melanoma (2)
- Vulvar Melanoma (1)
- Vulvar Squamous Cell Carcinoma (1)
Description: Species: human - male, 18 years old, CaucasianIsoenzyme: G6PD, BHistopathology: normalNote: The ...
Description: COR-L23/5010 has been derived from the parent line, COR-L23 by continuous exposure to increasing ...
Description: The cell line COR-L23/CPR is a drug-resistant variant of COR-L23. The line was developed by growing ...
Description: The cell line COR-L23/R is a multi-drug resistant (MDR) sub-line derived from the parent line ...
Description: The revertant lung cancer cell line COR-L23/R23- was generated by growing the doxorubicin-selected, ...
Description: A human lung adenocarcinoma cell line - parent to various drug resistant MOR cell lines also ...
Description: The drug resistant cell line MOR/0.2R has been derived from the parent line, MOR, by continuous ...
Description: MOR/0.4R has been developed from the parent line, MOR, by continuous exposure to increasing ...
Description: MOR/CPR has been developed by growing the parent line, MOR, in increasing concentrations of ...
Description: Species: human - male, 53 years old, CaucasianTumorigenecity: Yes, produces tumors in nude mice ...
Description: Species: human - male, 47 years old, CaucasianTumorigenecity: does not produce tumorsIsoenzyme: ...
Description: Species: human - male, embryo, 3 months old, CaucasianIsoenzyme: G6PD, BHistopathology: SV40 ...