Hepatoma Cells

Hepatocellular carcinoma (HCC) is a complex malignancy characterized by significant molecular heterogeneity and a high propensity for drug resistance. Hepatoma cell lines serve as indispensable in vitro platforms for decoding the mechanisms of hepatic carcinogenesis, exploring metabolic dysregulation, and validating novel therapeutic targets.

Our Hepatoma Cell collection features highly characterized models, including gold-standard lines like HepG2 and Hep3B. These cells are essential for high-throughput toxicity screening, investigation of liver-specific signaling pathways (such as Wnt/β-catenin and PI3K/Akt), and the study of viral-induced hepatocarcinogenesis (HBV/HCV).

Validated Identity Metabolically Active Versatile Applications Global Shipping

Product List

Key Features & Research Capabilities

Our hepatoma cell lines provide reliable performance across diverse liver-related research domains:

Gold Standard ADME/Tox Models

Retention of key liver functions, including Albumin secretion and urea synthesis.
Presence of functional drug-metabolizing enzymes and transporters (e.g. , CYP450).
Ideal for Hepatotoxicity screening and pharmacokinetic profiling of drug candidates.

Molecular & Viral Diversity

Specific models with integrated HBV genome (e.g. , Hep3B) or high permissiveness to HCV replication ( e.g. , Huh7).
Characterized for AFP (Alpha-fetoprotein) production levels and TP53 mutation status.
Varied metastatic potential and growth kinetics to mimic different clinical stages of HCC.

Superior Quality & Reliability

Comprehensive STR profiling for rigorous cell line authentication.
Certified Mycoplasma-free with documented viability and doubling times.
Stable supply of low-passage cells to ensure consistent signaling responses.

FAQ

Which hepatoma cell line is most suitable for drug toxicity testing?

HepG2 is the most widely used model for toxicology due to its high degree of differentiation and metabolic profile that closely mimics normal human hepatocytes in many detoxification pathways.

How do these cell lines differ in terms of HBV/HCV research?

Hep3B contains integrated Hepatitis B virus sequences and is often used to study HBV-mediated oncogenesis. In contrast, Huh7 is the primary choice for Hepatitis C virus (HCV) replication studies due to its unique genetic permissive background.

Can I use these cells for 3D Spheroid or Organ-on-a-chip models?

Yes, many hepatoma lines like HepG2 readily form stable 3D spheroids, which enhance liver-specific gene expression and drug responses compared to traditional 2D monolayers, providing better in vivo correlation.

Do you offer multidrug-resistant (MDR) hepatoma models?

Our collection includes lines with inherent resistance to common chemotherapeutics like Sorafenib and 5-FU. These are vital for investigating efflux pump mechanisms (e.g. , P-gp/MDR1) and developing sensitizing agents.

Are the culture conditions different from standard cancer cell lines?

Most lines grow well in DMEM or RPMI 1640 with 10% FBS. However, some differentiated lines may benefit from specialized supplements to maintain metabolic activity. We provide detailed culture protocols for each product.

Filters Clear all filters