Hepatic Cells
The liver is a highly specialized metabolic organ that plays a major role in detoxification, drug metabolism, nutrition processing, immunological modulation, and bile generation. Hepatic cell populations are composed of parenchymal and non-parenchymal compartments that work together to maintain liver homeostasis and coordinate responses to damage, inflammation, fibrosis and regeneration.
Our hepatic cell collection provides comprehensive in vitro liver research models, including primary hepatocytes, hepatic stellate cells, Kupffer cells, liver endothelial cells, biliary epithelial cells, fetal liver cells, and liver-derived subcellular fractions. These products support applications in ADME/Tox, DILI assessment, fibrosis studies, liver disease modeling, immunology, and regenerative medicine research.
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Hepatic Cell
Products
8+
Liver Cell
Types
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Research
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Our Hepatic Cell Portfolio Highlights
Comprehensive Liver Cell Resources
Our portfolio encompasses major parenchymal and non-parenchymal liver cell populations for advanced hepatic research.
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Primary Human Hepatocytes
- Fresh and cryopreserved hepatocytes
- Single-donor and pooled donor preparations
- Plateable and suspension hepatocyte formats
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Hepatic Progenitor & Stellate Cells
- Human hepatic progenitor cells
- Human hepatic stellate cells (HSCs)
- Fluorescent protein-labeled stellate cell models
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Non-Parenchymal Liver Cells
- Liver sinusoidal endothelial cells
- Kupffer cells and biliary epithelial cells
- Liver mononuclear and mixed NPC populations
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Specialized Hepatic Research Tools
- Human liver microsomes and S9 fractions
- Fetal liver-derived progenitor populations
- Liver tumor-associated cell models
Liver Research Applications
These hepatic cell models support studies of liver physiology, disease mechanisms, toxicology, and translational drug development.
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Drug Metabolism & Pharmacokinetics
Primary hepatocytes, microsomes, and S9 fractions are widely used for ADME profiling, CYP450 studies, drug-drug interaction assessments, and metabolic stability testing.
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Hepatotoxicity Assessment
Human liver cells provide predictive in vitro platforms for evaluating drug-induced liver injury (DILI), hepatotoxicity mechanisms, and compound safety.
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Liver Fibrosis & Inflammation Research
Hepatic stellate cells, Kupffer cells, and sinusoidal endothelial cells enable investigations of fibrosis progression, inflammation, extracellular matrix remodeling, and chronic liver diseases.
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Liver Cancer & Regenerative Medicine
Hepatic progenitor cells, fetal liver-derived cells, and liver carcinoma epithelial cells support studies of liver regeneration, stem cell biology, tumor progression, and therapeutic development.
What types of liver cells are available?
Our portfolio includes primary hepatocytes, hepatic progenitor cells, hepatic stellate cells, liver sinusoidal endothelial cells, Kupffer cells, biliary epithelial cells, liver mononuclear cells, and fetal liver-derived cell populations.
Do you provide pooled and single-donor hepatocytes?
Yes. We offer both pooled-donor hepatocytes and single-donor hepatocyte preparations, including plateable, suspension, and induction-qualified hepatocyte formats.
Are liver microsomes and S9 fractions available?
Yes. Human liver microsomes and S9 fractions from pooled donors are available for drug metabolism, enzyme activity, and pharmacokinetic studies.
Which cells are suitable for liver fibrosis research?
Human hepatic stellate cells are the primary model for fibrosis studies. Kupffer cells and liver sinusoidal endothelial cells are also commonly used to investigate fibrogenesis and inflammatory signaling.
What applications are supported by these hepatic cell models?
Applications include drug metabolism and ADME studies, hepatotoxicity screening, liver fibrosis research, inflammation studies, liver cancer biology, regenerative medicine, and biomarker discovery.