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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrust to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Immortalized Mouse Schwann Cells are derived from Twitcher mice. The Schwann cells...
Description: Immortalized Mouse Distal Tubule KDT3 Cells are spontaneously immortal derived cells...
Description: A spontaneously immortalized cell clone arisen from isolated adipose-derived stem...
Description: Immortalized Mouse Subcutaneous Adipose Multipotent Mesenchymal Cells (m17.ASC-GFP)...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: Immortalized Mouse Floxed Fam20c Osteoblast Cells are a reliable tool to study osteoblasts...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: Immortalized MHC II -/- Mouse Macrophage Cells (C2Dt) is derived from the knockout...
Description: Immortalized Mouse Proximal Tubule KPT2 Cells are spontaneously immortal derived...
Description: Immortalized Rat Embryonic Striatal (M213-2O) Cells - tsSV40T has GABAgeric properties...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: Immortalized Mouse CD81−/− Macrophage Cells (ASD1) is established from the long bones...
Description: Immortalized MHC II -/- Mouse Macrophage Cells (C2D) is derived from the knockout...
Description: Immortalized Rat Embryonic Striatal (M26-1F) Cells - tsSV40T has GABAgeric properties...
