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Immortalized Murine Cells

Immortalized Murine Cells.jpgMurine cells show frequent spontaneous immortalization in contrust to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of  cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway. Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.

Description: Olfactory bulb ensheating glia (OEG) is valued for its unique properties in promoting...

Cat#: CSC-I9081L INQUIRY

Description: In aldosterone-sensitive distal nephron (ASDN), mineralocorticoid receptor (MR) and...

Cat#: CSC-I9092L INQUIRY

Description: As messengers bridging the innate and adaptive immune system, the conventional tissue-resident...

Cat#: CSC-I9098L INQUIRY

Description: Enteroglial cells (EGCs) have a key role in the inflammatory response in the enteric...

Cat#: CSC-I9143L INQUIRY

Description: Lutropin/choriogonadotropin (LH/CG) receptor, a receptor uniquely expressed in ovarian...

Cat#: CSC-I9174L INQUIRY

Description: The Immortalized Mouse Astrocytes- SV40 T (IMA 2.1) is a suitable cell line for studies...

Cat#: CSC-I9175L INQUIRY

Description: Clara cells play a role in the maintenance of normal bronchiolar epithelium by secreting...

Cat#: CSC-I9178L INQUIRY

Description: Homeostasis of the central nervous system (CNS) is maintained by the blood brain...

Cat#: CSC-I9179L INQUIRY

Description: The Immortalized Mouse Mammary Epithelial Cells (iMMEC) is derived by co-expression...

Cat#: CSC-I9180L INQUIRY

Description: The Immortalized Mouse Prostate Epithelial Cells (iMPEC, clone7) is derived by co-expression...

Cat#: CSC-I9181L INQUIRY

Description: YAMC is a conditionally immortalized mouse colon epithelial cell line isolated from...

Cat#: CSC-I9183L INQUIRY

Description: The Immortalized Ovarian Surface Epithelial Cells (iMOSEC) is derived by co-expression...

Cat#: CSC-I9184L INQUIRY

Description: The mammalian cerebellum is indispensable in the coordination of voluntary movement...

Cat#: CSC-I9185L INQUIRY

Description: The Immortalized Baby Mouse Kidney Epithelial Cells (iBMK, Clone W2) is derived by...

Cat#: CSC-I9186L INQUIRY

Description: ImSt is a conditionally immortalized mouse stomach epithelial cell line isolated...

Cat#: CSC-I9187L INQUIRY

Description: IMPE is a conditionally immortalized mouse pancreas epithelial cell line isolated...

Cat#: CSC-I9189L INQUIRY

For research use only. Not for any other purpose.