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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Immortalized Mouse Primary Prostate Smooth Muscle Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Proximal Tubular Epithelial Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Pulmonary Artery Endothelial Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Pulmonary Artery Fibroblasts-SV40T provided by Creative...
Description: Immortalized Mouse Primary Pulmonary Vein Endothelial Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Pulmonary Vein Fibroblasts-SV40T provided by Creative...
Description: Immortalized Mouse Primary Retinal Microvascular Endothelial Cells-SV40T provided...
Description: Immortalized Mouse Primary Skeletal Muscle Microvascular Endothelial Cells-SV40T...
Description: Immortalized Mouse Primary Small Intestinal Epithelial Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Small Intestinal Fibroblasts-SV40T provided by Creative...
Description: Immortalized Mouse Primary Small Intestinal Microvascular Endothelial Cells-SV40T...
Description: Immortalized Mouse Primary Small Intestinal Smooth Muscle Cells-SV40T provided by...
Description: Immortalized Mouse Primary Spleen Endothelial Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Spleen Epithelial Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Spleen Fibroblasts-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Stomach Epithelial Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Stomach Smooth Muscle Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Thymus Endothelial Cells-SV40T provided by Creative Bioarray...
