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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Immortalized Mouse Primary Artery Fibroblasts-GFP provided by Creative Bioarray have...
Description: Immortalized Mouse Primary Artery Smooth Muscle Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Bladder Epithelial Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Bladder Microvascular Endothelial Cells-GFP provided by...
Description: Immortalized Mouse Primary Bladder Smooth Muscle Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Bone Marrow-Derived Endothelial Cells-GFP provided by...
Description: Immortalized Mouse Primary Brain Microvascular Endothelial Cells-GFP provided by...
Description: Immortalized Mouse Primary Brain Vascular Fibroblasts-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Brain Vascular Smooth Muscle Cells-GFP provided by Creative...
Description: Immortalized Mouse Primary Bronchial Epithelial Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Cardiac Fibroblasts-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Cardiac Microvascular Endothelial Cells-GFP provided by...
Description: Immortalized Mouse Primary Carotid Artery Endothelial Cells-GFP provided by Creative...
Description: Immortalized Mouse Primary Colonic Epithelial Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Colonic Fibroblasts-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Colonic Microvascular Endothelial Cells-GFP provided by...
Description: Immortalized Mouse Primary Colonic Smooth Muscle Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Corneal Epithelial Cells-GFP provided by Creative Bioarray...
