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Immortalized Murine Cells

Immortalized Murine Cells.jpgMurine cells show frequent spontaneous immortalization in contrust to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of  cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway. Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.

Description: The Immortalized Mouse Cardiomyogenic Progenitor Cells are hygromycin-resistant,...

Cat#: CSC-I9226L INQUIRY

Description: Immortalized Mouse Dental Apical Papilla Progenitor Cells are hygromycin-resistant...

Cat#: CSC-I9227L INQUIRY

Description: Intestinal epithelial cells provide a protective barrier against bacteria, antigens...

Cat#: CSC-I9228L INQUIRY

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Cat#: CSC-I9229L INQUIRY

Description: Immortalized Mouse Achilles Tendon Cells (iMAT) are derived from the Achilles tendon...

Cat#: CSC-I9232L INQUIRY

Description: Epidermal melanocytes are melanin-producing cells that function as a protective mechanism...

Cat#: CSC-I9233L INQUIRY

Description: Epidermal melanocytes are melanin-producing cells that function as a protective mechanism...

Cat#: CSC-I9235L INQUIRY

Description: Epidermal melanocytes are melanin-producing cells that function as a protective mechanism...

Cat#: CSC-I9237L INQUIRY

Description: Kaposi’s sarcoma-associated herpesvirus (KSHV) has been linked to several malignancies...

Cat#: CSC-I9241L INQUIRY

Description: The Immortalized Mouse CD4+CD8+T Cells (MOHITO) has characteristics of an immortalized...

Cat#: CSC-I9242L INQUIRY

Description: Immortalized Mouse Renal Proximal Tubule Cells-SV40 have been obtained immortalizing...

Cat#: CSC-I9243L INQUIRY

Description: Odontoblasts are useful in studying the development of mineralized tissue, such as...

Cat#: CSC-I9246L INQUIRY

Description: Immortalized Rat Suprachiasmatic Nucleus Cells (SCN2.2) is pluripotent and has the...

Cat#: CSC-I9247L INQUIRY

Description: Epidermal melanocytes are melanin-producing cells that function as a protective mechanism...

Cat#: CSC-I9249L INQUIRY

Description: During preganancy the myometrium undergoes hypertrophy and hyperplasia. The established...

Cat#: CSC-I9251L INQUIRY

Description: The Immortalized Mouse Urogenital Sinus Mesenchymal Cells (UGSM-2) are derived from...

Cat#: CSC-I9252L INQUIRY

Description: The Immortalized Mouse Leptin Receptor-deficient Macrophage Cells (DB-1) are non-transformed...

Cat#: CSC-I9253L INQUIRY

For research use only. Not for any other purpose.