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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Immortalized Mouse Primary Thyroid Epithelial Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Thyroid Microvascular Endothelial Cells-SV40T provided...
Description: Immortalized Mouse Primary Tracheal and Bronchial Epithelial Cells-SV40T provided...
Description: Immortalized Mouse Primary Tracheal and Bronchial Fibroblasts-SV40T provided by Creative...
Description: Immortalized Mouse Primary Tracheal Smooth Muscle Cells-SV40T provided by Creative...
Description: Immortalized Mouse Primary Uterine Microvascular Endothelial Cells-SV40T provided...
Description: Immortalized Mouse Primary Vein Endothelial Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Primary Vein Fibroblasts-SV40T provided by Creative Bioarray have...
Description: Immortalized Mouse Primary Vein Smooth Muscle Cells-SV40T provided by Creative Bioarray...
Description: Immortalized Mouse Bone Marrow Macrophages-GFP provided by Creative Bioarray have...
Description: Immortalized Mouse Bone Marrow Mesenchymal Stem Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Bone Marrow Monocytes-GFP provided by Creative Bioarray have been...
Description: Immortalized Mouse Bone Marrow Neutrophils-GFP provided by Creative Bioarray have...
Description: Immortalized Mouse Liver Kupffer Cells-GFP provided by Creative Bioarray have been...
Description: Immortalized Mouse Primary Alveolar Epithelial Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Aortic Endothelial Cells-GFP provided by Creative Bioarray...
Description: Immortalized Mouse Primary Aortic Fibroblasts-GFP provided by Creative Bioarray have...
Description: Immortalized Mouse Primary Aortic Smooth Muscle Cells-GFP provided by Creative Bioarray...
