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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrust to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: The Immortalized Mouse Hepatocyte SIMHCLOCKCells contain a bioluminescent marker...
Description: Immortalized Mouse Leydig Cells (D-4-4) are derived from MT-PVLT-10 transgenic mice...
Description: Alveolar macrophages were isolated from the brochoalveolar lavage fluid of MARCO-/-SR-AI/II-/-(MS-/-)...
Description: The Immortalized Mouse Wildtype M4+/+Epidermal Keratinocyte Cells were derived from...
Description: The Immortalized Mouse Neuronal Cells (M4b) were derived from the spinal cord of...
Description: The Immortalized Immortalized Mouse EGFR Mutant M3-/-Epidermal Keratinocytes were...
Description: The Immortalized Rat Retinal Capillary Endothelial Cells are immortalized with SV40...
Description: The Immortalized Mouse EGFR Mutant M4-/-Epidermal Keratinocytes were derived from...
Description: The Immortalized Bcl-x Mouse Embryonic Fibroblasts - SV40T were derived from primary...
Description: The Immortalized Mouse Hepatic Stellate Cells – SV40 were derived from C57/Bl6 WT...
Description: The Immortalized Mouse Atrioventricular Cushion Mesenchymal Cells (tsA58-AVM) were...
Description: The Immortalized Trisomy 16 Mouse Neuronal Cells (MTh) were derived from the spinal...
Description: The Immortalized Mouse WildType Aortic Endothelial Cells (iMAEC-WT) were derived...
Description: The Immortalized Mouse Hepatic Stellate Cells were derived from MyD88-/-mouse via...
