Peripheral Blood Mononuclear Cells

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Peripheral blood mononuclear cells (PBMCs) are cells with a single, round nucleus and are collected from the peripheral or circulating blood by density centrifugation with Ficoll, a polysaccharide. PBMCs include dendritic cells, monocytes, and lymphocytes (T, B, and NK cells). T cells are CD3+ and further classified into helper T cells (TH) that express CD4 and cytotoxic T cells (TC) that express CD8. B cells are characterized by CD19 expression and respond to pathogens by producing a large number of antigen-specific antibodies to neutralize foreign objects. NK cells are CD56+CD3-, which originate from the same progenitor cells as T and B cells, but lack the antigen receptor. Finally, monocytes are the largest type of PBMCs and express CD14. They circulate in the bloodstream for 1-3 days and then usually move into tissues throughout the body, where they can differentiate into macrophages and myeloid-lineage dendritic cells.

Cell TypePercentage in PBMCsMarkersFunction
CD4+ T cells25-60%CD3+CD4+Coordinate adaptive immunity through activation and regulation of other immune cells
CD8+ T cells5-30%CD3+CD8+Destroy cancer cells or cells that are infected or damaged
B cells5-10%CD19+Secrete antibodies as part of humoral immune response
NK cells10-30%CD56+CD3-Trigger lysis or apoptosis of infected cells
Monocytes5-10%CD14+Take up foreign objects via phagocytosis, perform antigen presentation, and produce cytokines
Dendritic cells1-2%
Process and present antigen material to T cells

PBMCs are a powerful tool for research and clinical studies related to human health and disease. By efficient and successful processing and analysis of PBMCs, researchers and clinicians can evaluate immune responses, gain a deeper understanding of the immune system, and apply their findings to the treatment of human diseases. PBMC are now readily available from many commercial sources, with samples isolated from both healthy and diseased individuals.

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Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7638W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7639W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7640W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7641W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7642W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7643W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7644W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7645W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7646W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7647W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7648W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7649W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7650W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7652W INQUIRY

Description: Cryopreserved Human Peripheral Blood Mononuclear Cells are available as positive...

Cat#: CSC-7654W INQUIRY

Description: CD34 is a well-known marker for primitive and bone marrow-derived progenitor cells...

Cat#: CSC-7674W INQUIRY

Description: CD34 is a well-known marker for primitive and bone marrow-derived progenitor cells...

Cat#: CSC-7675W INQUIRY

Description: Creative Bioarray Mononuclear Cells (MNC) represent the enriched lymphocyte and monocyte...

Cat#: CSC-C4033X INQUIRY

For research use only. Not for any other purpose.