SARS-CoV-2 Concerning Cell Lines
The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China, and its rapid national and international spread pose a global health emergency. At the same time, scientific research on biology of the virus as well as on new diagnostic and therapeutic means is a demanding, urgent task for both academic institutions and pharmaceutical industry. During this global health emergency, Creative Bioarray is committed to supporting researchers worldwide engaged in this field.
Creative Bioarray maintains various human and animal cell lines, which is valuable for medical, scientific and pharmaceutical research associated with COVID-19. So far, numerous cell lines have been demonstrated as powerful tools for SARS-CoV-2 research. On this basis, we are capable of providing a variety of cell lines that are well-suitable for SARS-CoV-2 studies. Explore our SARS-CoV-2 concerning cell lines in the table below.
Available Cell Lines for COVID-19/SARS-CoV-2 Research
| Cat. No. | Product Name | Cell Type |
| Commonly Used Cell Lines for COVID-19 Research | ||
| CSC-C6236X | A-549 | Human Lung Adenocarcinoma Cell Line |
| CSC-C2006 | BHK-21 | Hamster Kidney Fibroblast Cell Line |
| CSC-C3431 | HEK 293T | Human Embryonic Kidney Cell Line |
| CSC-C9441L | HUH7 | Human Liver Carcinoma Cell Line |
| CSC-C8867H | MDCK | Madin-Darby Canine Kidney Cell Line |
| CSC-C9580L | PK-15 | Pig Kidney Cell Line |
| CSC-C8963H | VERO | Monkey Kidney Cell Line |
| CSC-C2768 | VERO-B4 | Monkey Kidney Cell Line |
| CSC-C9750L | VERO 76 | Monkey Kidney Cell Line |
| CSC-C8227L | U937 | Human Acute Monocytic Leukemia Cell Line |
| ACE2 Enhanced Cell Lines | ||
| CSC-C0487 | BEWO | Human Choriocarcinoma Cell |
| CSC-C8977H | HaCaT | Immortalized Human Keratinocyte Cell |
| CSC-C0313 | HepG2 | Human Hepatocellular Carcinoma Cell |
| CSC-C0328 | NB-4 | Human Acute Promyelocytic Leukemia Cell |
| CSC-C0447 | RPMI-8226 | Human Myeloma Cell Lines |
| CSC-C0329 | SH-SY5Y | Human Neuroblastoma Cell Line |
| TMPRSS2 Enhanced Cell Lines | ||
| CSC-C8200L | Caco-2 | Human Epithelial Colorectal Adenocarcinoma Cell Line |
| CSC-C0262 | MCF-7 | Human Breast Cancer Cell Line |
| CSC-C8936H | SK-BR-3 | Human Breast Cancer Cell Line |
| CSC-C2512 | T-47D | Human Breast Cancer Cell Line |
| ACE2 and TMPRSS2 Co-Enhanced Cell Line | ||
| CSC-C0455 | RT4 | Human Bladder Carcinoma Cell Line |
| Overexpression Cell Lines | ||
| CSC-RO0643 | S Protein Stable Cell Line - CHO | Chinese Hamster Ovary-Derived Cell Line |
| CSC-RO0644 | S Protein Stable Cell Line - HEK293 | Human Embryonic Kidney-Derived Cell Line |
| CSC-RO0290 | hACE2 Stable Cell Line - COS7 | Monkey Kidney Fibroblast-Derived Cell Line |
| CSC-RO0291 | hACE2 Stable Cell Line - NIH-3T3 | Mouse Embryonic Fibroblast-Derived Cell Line |
| CSC-RO0289 | hACE2 Stable Cell Line - HeLa | Human Cervical Cancer Cell-Derived Cell Line |
| CSC-RO0292 | hACE2 Stable Cell Line - HEK293 | Human Embryonic Kidney-Derived Cell Line |
| CSC-RO0293 | hACE2 Stable Cell Line - CHO-K1 | Chinese Hamster Ovary-Derived Cell Line |
| CSC-RO0641 | hACE2 Stable Cell Line-HEK293T | Human Embryonic Kidney-Derived Cell Line |
| CSC-RO0642 | hACE2 Stable Cell Line - A549 | Human Lung Carcinoma-Derived Cell Line |
| Knockout (KO) Cell Lines | ||
| CSC-RT2688 | hACE2 KO Cell Line - HEK293T | Human Embryonic Kidney-Derived Cell Line |
| CSC-RT2689 | TMPRSS2 KO Cell Line - HEK293T | Human Embryonic Kidney-Derived Cell Line |
Certainly, we can provide more cell lines, which also may be of interest in the field of SARS-CoV-2 research. In addition, we can also support you in the following services:
- Analysis of cells targeted by SARS-CoV-2
We can assist you to identify which cell lines express ACE2 and/or TMPRSS2, utilizing single-cell RNA sequencing technology to large-scale analyze certain gene expressions in a given cell type; or western blot for low-throughput analysis.
- Generation of SARS-CoV-2 pseudovirus infected cell lines
Creative Bioarray employs pseudoviruses of SARS-CoV-2 to infect target cell lines of novel coronavirus. Pseudoviruses do not contain viral nucleic acid but have the necessary components for cell entry and viral infection.
- Characterization of SARS-CoV-2 pseudovirus infected cell lines
Following the pseudoviruses infection, FACS assays, qPCR, Cell Viability assays can be conducted in Creative Bioarray to confirm the presence of S protein of SARS-CoV-2 in the infected cells.
Feel Free to Contact Us
Didn't see any cell lines or services you are interested in for your COVID-19 research?
More cell lines and customized services are available in Creative Bioarray. For more information on our product categories and service capabilities, do not hesitate to contact us for more details.
References
- Letko M, et al. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature microbiology. 2020 Apr;5(4):562-9.
- Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 Mar 5.
- Kleine-Weber H, Elzayat MT, Hoffmann M, Pöhlmann S. Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein. Scientific reports. 2018 Nov 9;8(1):1-1.
- Hattermann K, Müller MA, Nitsche A, Wendt S, Mantke OD, Niedrig M. Susceptibility of different eukaryotic cell lines to SARS-coronavirus. Archives of virology. 2005 May 1;150(5):1023-31.
