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SARS-CoV-2 Concerning Cell Lines

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The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China, and its rapid national and international spread pose a global health emergency. At the same time, scientific research on biology of the virus as well as on new diagnostic and therapeutic means is a demanding, urgent task for both academic institutions and pharmaceutical industry. During this global health emergency, Creative Bioarray is committed to supporting researchers worldwide engaged in this field.

Creative Bioarray maintains various human and animal cell lines, which is valuable for medical, scientific and pharmaceutical research associated with COVID-19. So far, numerous cell lines have been demonstrated as powerful tools for SARS-CoV-2 research. On this basis, we are capable of providing a variety of cell lines that are well-suitable for SARS-CoV-2 studies. Explore our SARS-CoV-2 concerning cell lines in the table below.

Available Cell Lines for COVID-19/SARS-CoV-2 Research

Cat. No. Product NameCell Type
Commonly Used Cell Lines for COVID-19 Research
CSC-C6236XA-549Human Lung Adenocarcinoma Cell Line
CSC-C2006BHK-21Hamster Kidney Fibroblast Cell Line
CSC-C3431HEK 293THuman Embryonic Kidney Cell Line
CSC-C9441LHUH7Human Liver Carcinoma Cell Line
CSC-C8867HMDCKMadin-Darby Canine Kidney Cell Line
CSC-C9580LPK-15Pig Kidney Cell Line
CSC-C8963HVEROMonkey Kidney Cell Line
CSC-C2768VERO-B4Monkey Kidney Cell Line
CSC-C9750LVERO 76Monkey Kidney Cell Line
CSC-C8227LU937Human Acute Monocytic Leukemia Cell Line
ACE2 Enhanced Cell Lines
CSC-C0487BEWOHuman Choriocarcinoma Cell
CSC-C8977HHaCaTImmortalized Human Keratinocyte Cell
CSC-C0313HepG2Human Hepatocellular Carcinoma Cell
CSC-C0328NB-4Human Acute Promyelocytic Leukemia Cell
CSC-C0447RPMI-8226Human Myeloma Cell Lines
CSC-C0329SH-SY5YHuman Neuroblastoma Cell Line
TMPRSS2 Enhanced Cell Lines
CSC-C8200LCaco-2Human Epithelial Colorectal Adenocarcinoma Cell Line
CSC-C0262MCF-7Human Breast Cancer Cell Line
CSC-C8936HSK-BR-3Human Breast Cancer Cell Line
CSC-C2512T-47DHuman Breast Cancer Cell Line
ACE2 and TMPRSS2 Co-Enhanced Cell Line
CSC-C0455RT4Human Bladder Carcinoma Cell Line
Overexpression Cell Lines
CSC-RO0643S Protein Stable Cell Line - CHOChinese Hamster Ovary-Derived Cell Line
CSC-RO0644S Protein Stable Cell Line - HEK293Human Embryonic Kidney-Derived Cell Line
CSC-RO0290hACE2 Stable Cell Line - COS7Monkey Kidney Fibroblast-Derived Cell Line
CSC-RO0291hACE2 Stable Cell Line - NIH-3T3Mouse Embryonic Fibroblast-Derived Cell Line
CSC-RO0289hACE2 Stable Cell Line - HeLaHuman Cervical Cancer Cell-Derived Cell Line
CSC-RO0292hACE2 Stable Cell Line - HEK293Human Embryonic Kidney-Derived Cell Line
CSC-RO0293hACE2 Stable Cell Line - CHO-K1Chinese Hamster Ovary-Derived Cell Line
CSC-RO0641hACE2 Stable Cell Line-HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RO0642hACE2 Stable Cell Line - A549Human Lung Carcinoma-Derived Cell Line
Knockout (KO) Cell Lines
CSC-RT2688hACE2 KO Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line
CSC-RT2689TMPRSS2 KO Cell Line - HEK293THuman Embryonic Kidney-Derived Cell Line

Certainly, we can provide more cell lines, which also may be of interest in the field of SARS-CoV-2 research. In addition, we can also support you in the following services:

  • Analysis of cells targeted by SARS-CoV-2

We can assist you to identify which cell lines express ACE2 and/or TMPRSS2, utilizing single-cell RNA sequencing technology to large-scale analyze certain gene expressions in a given cell type; or western blot for low-throughput analysis.

  • Generation of SARS-CoV-2 pseudovirus infected cell lines

Creative Bioarray employs pseudoviruses of SARS-CoV-2 to infect target cell lines of novel coronavirus. Pseudoviruses do not contain viral nucleic acid but have the necessary components for cell entry and viral infection.

  • Characterization of SARS-CoV-2 pseudovirus infected cell lines

Following the pseudoviruses infection, FACS assays, qPCR, Cell Viability assays can be conducted in Creative Bioarray to confirm the presence of S protein of SARS-CoV-2 in the infected cells.

Feel Free to Contact Us

Didn't see any cell lines or services you are interested in for your COVID-19 research?

More cell lines and customized services are available in Creative Bioarray. For more information on our product categories and service capabilities, do not hesitate to contact us at or 1-631-626-9181 for more details.

References

  1. Letko M, et al. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature microbiology. 2020 Apr;5(4):562-9.
  2. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 Mar 5.
  3. Kleine-Weber H, Elzayat MT, Hoffmann M, Pöhlmann S. Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein. Scientific reports. 2018 Nov 9;8(1):1-1.
  4. Hattermann K, Müller MA, Nitsche A, Wendt S, Mantke OD, Niedrig M. Susceptibility of different eukaryotic cell lines to SARS-coronavirus. Archives of virology. 2005 May 1;150(5):1023-31.
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