Mouse soluble ICAM-1 is a recombinant protein derived from the cell adhesion molecule ICAM-1 (CD54). ICAM-1 has a molecular =mass of approximately 95 kDa. It is a membrane protein expressed on many cell types and its expression is upregulated upon cell activation. It binds to two integrins on leukocytes, namely LFA-1 and Mac-1. Cell adhesion mediated by these molecules is critical for a wide range of cellular interactions in the immune system, including leukocyte adhesion to endothelial cells and interaction between T cells and antigen-presenting cells. The adhesion of leukocytes to ICAM-1 requires functional activation of LFA-1 or Mac-1 on leukocytes. Purified sICAM-1 adsorbed to a solid support binds activated cells expressing LFA-1 or Mac-1, but not resting cells. This binding can be blocked by the monoclonal anti-ICAM-1 antibody (in mouse with clone YN1/1; Catalog #01503), anti-LFA-1 or anti-Mac-1, indicating a direct interaction of these molecules in cell adhesion. Soluble ICAM is useful for the studies of the activation of leukocyte adhesion in immune responses and inflammatory reactions.
Mouse Icam1 expressed in NS-1
Soluble ICAM-1 is produced in NS-1 cells.
CAT# CSC-CTK0036-100 (100 μg); CAT# CSC-CTK0036-500 (500 μg)
Please refer to PIS (Product Information Sheet)
Storage & Stability
Product stable at -20°C (-25°C to -15°C) until expiry date indicated on label. Avoid repeated freezing and thawing.
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