CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal "mucin-like stalk" sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog). Recombinant human CXCL16 is a 10.1 kDa protein containing 89 amino acid residues.
Human CXCL16 expressed in E.coli
CAT# CSC-CTK0495-25 (25 μg); CAT# CSC-CTK0495-125 (125 μg)
Greater than 98% as determined by SDS-PAGE analysis.
Determined by its ability to chemoattract activated lymphocytes using a concentration of 1.0- 100.0 ng/ml.
Less than 1 EU/μg.
Lyophilized from a sterile-filtered solution with no additives.
Please centrifuge product briefly before opening the vial. Reconstitute in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized powder, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted CXCL16 should be used immediately or stored in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
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