CRISPR/Cas-9 is a new genomic editing system that has the potential to revolutionize basic biomedical research and, possibly, the treatment of genetic disease. The CRISPR/Cas9 system, consisting of a guide RNA (gRNA) and a Cas9 nuclease, allows researchers to create a RNA-guided site-specific DNA cleavage. Creative Bioarray is able to use the double strand break created to modify your target gene by inducing a permanent knock-out, conditional knock-out, point mutation, or insertion.
Genome manipulation of human induced pluripotent stem (iPS) cells is essential to achieve their full potential as tools for regenerative medicine. Creative Bioarray focused on induced pluripotent stem cells (iPSCs) for a long time. We have excellent capabilities of correcting mutations in disease-model iPSCs using CRISPR/ Cas9. Save time and effort by having our genome engineering experts develop your CRISPR/Cas9 system.
Cas9 is targeted to DNA by a guide RNA that forms base pairs to itself and to the DNA target.
Cleavage occurs on both strands (red X) 3 bp upstream of the PAM
If you have any special needs in CRISPR/Cas9 service, please contact us at firstname.lastname@example.org or 1-631-626-9181 for this special service. Let us know what you need and we will accommodate you. Creative Bioarray can be a valuable resource and partner for your organization.