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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Cell Migration and Invasion Assay Services

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Other migration assays

Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation. Methods to examine cell migration are very useful and important for a wide range of biomedical research such as cancer biology, immunology, vascular biology, cell biology and developmental biology. With comprehensive list of cell lines in our inventory, Creative Bioarray provides cell migration and Invasion Assay Services to all of our customers.

Creative Bioarray Cell Migration and Invasion Assay advantages

• Assays are performed using various types of cells: Cell lines, Primary human or murine keratinocytes, Primary human or murine fibroblasts
• Quantitative, Real time detection
• High sensitivity
• Choose suitable cell migration assay format according to the customer’s requirements.

Technique and procedures

Two main types of methods are available at Creative Bioarray:

Cell culture wound-healing assays

The wound-healing assay is simple, inexpensive method to study directional cell migration in vitro. This method mimics cell migration during wound healing in vivo. A “wound” is generated on a confluent cell monolayer. The speed of wound closure and cell migration can be quantified by taking snapshot pictures with a regular inverted microscope at several time intervals. More detailed cell migratory behavior can be documented using the time-lapse microscopy system.

Suitable Applications: Measure differences in migration rates between treated and untreated cells.

Other migration assays

Wound-healing assays based on (A) scratching, (B) stamping, (C) solid barrier, (D) liquid barrier, (E) droplet chemical assay, (F) microfluidic chemical assay, (G) electrical assay, and (H) laser ablation.

Transwell cell migration and invasion assay (Boyden chamber assay)

Transwell migration assays have been widely used for studying the motility of different types of cells including metastatic cancer cells. By using this method, we measure the capacity of cell motility and invasiveness toward a chemo-attractant gradient.

Suitable Applications: Measure effect of chemoattractant on migration rates

Other migration assays

Other migration assays available

• Cell exclusion zone assay
• Fence assay (ring assay)
• Microcarrier bead assay
• Spheroid migration
• Capillary chamber migration assays (microfluidic chamber assays).

Other migration assays

Other migration assays

Study Examples

Results for wound-healing assays

Figure1: Results for wound-healing assays

Transwell migration and invasion assays of T24 and  5637 bladder urothelial cancer cells

Figure 2: Transwell migration and invasion assays of T24 and 5637 bladder urothelial cancer cells.

Quotations and ordering

Call us today at 631-626-9181, or email us at info@creative-bioarray.com for a quotation or if any questions! Our customer service representatives are available 24hr a day!

References

1. Nina, K.; et al. In vitro cell migration and invasion assays. Mutation Research. 2013, 752: 10–24.

2. Calvin, R. Justus.; et al. In vitro cell migration and invasion assays. J Vis Exp. 2014, 88: e51046.

You may be interested in related cell assays as below:
Cell Cycle Assays
Cell Apoptosis Assays
Cell Viability Studies
Cell Proliferation Assays
SRB Assay
Toxicology Assay

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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com