Creative Bioarray is a leading company in histology service. We are dedicated to provide the most comprehensive list of histology service and custom design services to academia as well as industrial researchers and clinical institutes all around the world. We offer Fluorescence in situ hybridization (FISH) service range from standardized testing of validated assays to custom development of new assays. Drawing on many years of experiences and in-depth knowledge, we guarantee the speed, quality and cost of our service. Creative Bioarray is your first and most reliable choice in histology.
Fluorescence in situ hybridization (FISH), developed in 1980s, is a cytogenetic technique using fluorescent probes to bind the chromosome with a high degree of complementarity. It is a powerful and easy method to detect RNA or DNA sequences in cells, tissues and tumors. This technique is useful for identifying chromosomal abnormalities, gene mapping, characterizing somatic cell hybrids, checking amplified genes and studying the mechanism of rearrangements. RNA FISH is used to measure and localize mRNAs and other transcripts within tissue sections or whole mounts.
O'Connor, C. (2008) Fluorescence in situ hybridization (FISH). Nature Education 1(1):171
Creative Bioarray has excellent scientists and experts who has years of experience in histology and FISH. We fully understand the advantages and pitfalls of the technique. Cooperating with us could significantly increase the speed to acquire images and further to achieve your research goals.
Creative Bioarray's FISH services are flexible to meet your needs as follows:
- Sample Preparation
We have established proprietary protocols for slide preparation that enhance sensitivity and signal for multiple FISH applications, including:
- Cell chromosome FISH (interphase, metaphase and cultured cells)
- Tissue chromosome FISH (formalin-fixed, paraffin-embedded tissue or cell slides)
- RNA-FISH (intracellular RNA localization, RNA processing, quantitation).
- Probe Design, Labeling and Purification
Probes with superior sensitivity and specificity are designed using proprietary algorithms developed by our experts and are available with a wide selection of labels.
Several selected specific tests include but not limited to:
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Chronic lymphoblastic leukemia
- Chronic myelomonocytic leukemia
- Mantle cell lymphoma
- MALT lymphoma
We have experiences on developing SOPs to optimize FISH hybridization conditions for each custom assay.
We deliver publication-ready data and figures to our customers.
Before processing, our scientists will connect with you on experimental design and details of the project. Recommendations are given to help you get the best results in the most cost-effective and fastest way.
As an important routine technique, FISH could be very time consuming. Creative Bioarray fully understands the details and pitfalls of FISH and histology. We will work side-by-side with you to find the best design to achieve your aims. Our service is efficient and reliable with relatively low cost.
If you have any special needs in detecting and locating specific RNA targets by FISH, please contact us at firstname.lastname@example.org or 1-631-626-9181 for this special service. Let us know what you need and we will meet your requirements. We look forward to working with you.