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Invasion and metastasis are responsible for the high morbidity and mortality in cancer patients. Invasion into the surrounding normal tissues is generally considered to be a key hallmark of malignant tumors. More efforts for anticancer drug development now move towards therapies that targeted on the inhibition of this key ‘hallmark’ of cancer. The 3D tumor spheroid invasion assay allows cells to invade out of the tumor mass into the extracellular matrix-like environment. The true 3D manner takes into account important aspects of the pathophysiology of a tumor mass, in which the tumor spheroids may experience hypoxia and nutrient deprivation which may cause the change in gene ex
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3D tumor spheroids invasion assays: Multicellular spheroids are embedded into 3D ECM. It is expected to see that non-invasive cancer cells stay as compact spheroids with a distinct border to the surrounding ECM and do not show any obvious signs of invasion. However, invasive cells or endothelial cells start to invade into the surrounding matrix and display outgrowth from the spheroids.
Figure 1 The representative images for 3D invasion assay for glioblastoma spheroids
Figure 2 The representative image analysis of 3D invasion assay for glioblastoma spheroids
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|1.||Vinci, M., et al. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC biology. 2012, 10.1: 29.|
|2.||Kramer, N., et al. In vitro cell migration and invasion assays. Mutation Research/Reviews in Mutation Research. 2013, 752.1: 10-24.|
|3.||Vinci, M M., et al. Three-dimensional (3D) tumor spheroid invasion assay. JoVE (Journal of Visualized Experiments). 2015, 99: e52686-e52686.|
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