Alcoholic Gastric Ulcer Model
Gastric ulcer is a common gastrointestinal disorder that affects millions of people worldwide. To evaluate the anti-gastric ulcer activity of potential drug candidates, numerous rodent models have been developed. At Creative Bioarray, we provide an alcoholic gastric ulcer model that is induced in rats. Our models are designed to mimic the pathophysiology of gastric ulcers in humans, and we provide highly accurate and reproducible results to our clients.
Alcohol, as a potential risk factor for gastric ulcer development, can penetrate the gastric mucosa by solubilizing the protective mucous layer. This exposure subjects the mucosa to the proteolytic and hydrolytic actions of hydrochloric acid and pepsin, ultimately leading to membrane damage. Furthermore, alcohol stimulates acid secretion, disrupts vascular endothelium to reduce blood flow, and triggers the release of superoxide anion, thereby enhancing oxidative stress within the tissues.
Our Alcoholic Gastric Ulcer Model
- Animal Available
Rat - Modeling Method
At Creative Bioarray, we induce gastric ulcer by single gavage of alcohol in rats. - Endpoints
- Observation of stomach
- Blood/tissue collection
- H&E staining
- Serum analysis: TNF-α, IL-6, SOD, CAT, MDA, etc.
- qPCR or Western Blot
- Other customized endpoints: available upon request
Example Data
Fig. 1 Gastric ulcer area of ethanol-induced ulceration in rats. (A) Vehicle control; (B) ulcer control; (C) ExPhy (100 mg/kg); (D) ExPhy (200 mg/kg); (E) ExPhy (400 mg/kg); (F) omeprazole (40 mg/kg).
Fig. 3 ExPhy and omeprazole pretreatments, followed by ethanol-induced gastric ulcers, produced protective effects on the gastric mucosal activity of GPx, SOD and CAT, as well as lowering the levels of MDA compared to the ulcer control.
In addition, we also offer other gastric ulcer animal models that you may be interested in:
Quotation and Ordering
Creative Bioarray, as a leading CRO research partner for drug development, is dedicated to providing accurate and cost-effective services to our clients. If you are interested in our services, please do not hesitate to contact us at any time or submit an inquiry to us directly.
Reference
- Guzmán-Gómez, O., et al. Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima. Nutrients, 2018 Jun 13;10(6):763.
