tissue samples, tissue arrays, cells, microorganisms, probes and services for your research.
Cancer drug discovery relies mostly on testing the effects of therapeutics in tumor cell lines. However, drugs optimized to be highly effective on the 2D cultures are often lack of showing the expected efficacy on clinical trials. Substantial research efforts have demonstrated that 3D cell culture systems can better mimic and predict biological responses of living organisms. 3D in vitro tumor models are particularly useful to recapitulate tumor heterogeneity and microenvironment, fostering the discovery of therapeutics with improved clinical efficiency. Creative Bioarray believes that the evaluation of drug efficacy early during development can help to identify sources of potential drug resistance, and the read-outs of drug efficacy need to be capable of providing a specific quantitative measurement for our customers. Thus, we provide the adequacy of the assays for drug efficacy read-out measurements, and all these measurements are carefully evaluated and discussed.
Creative Bioarray drug efficacy test service advantages
Creative Bioarray provides comprehensive drug efficacy testing services with a variety of measurements:
Figure. The correlation between cell viability and 3D tumor spheroids size suppression for 3D ovarian cancer spheroids.
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|1.||Joshi, P.; Lee, M.Y. High content imaging (HCI) on miniaturized three-dimensional (3D) cell cultures. Biosensors (Basel), 2015, 5: 768-790.|
|2.||Santo, V.E., et al. Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs. Biotechnology journal, 2017, 12.|
|3.||Kijanska, M.; Kelm, J. In vitro 3D spheroids and microtissues: ATP-based cell viability and toxicity assays. Assay Guidance Manual (eds. Sittampalam, G.S., et al.), (Bethesda (MD), 2004).|
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