Online Inquiry & Support

USA: 1-631-626-9181   Fax: 1-631-614-7828
Europe: 44-207-097-1828
Email: info@creative-bioarray.com

SEARCH

tissue samples, tissue arrays, cells, microorganisms, probes and services for your research.

  

SEARCH

Contact Support
Interested in our Products & Services?
Need detailed information?
Can't find the products of interest?
Need it customized?
Click Here & Contact Support
Contact Us
    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
Ordering Information
    • Payment methods we support:
      ✭ Invoice / Purchase Order
      ✭ Credit card

ADME Testing

Bookmark and Share

ADME, an abbreviation for absorption, distribution, metabolism, and elimination, describes the disposition of drug candidates within an organism. ADME determine the drug levels and kinetics within a body, and hence influence the performance and bioactivity of the compound as a drug. Therefore, ADME assessment of candidate compounds is a crucial step in drug development before going to clinical trials.

Creative Bioarray offers standard, predictive and comprehensive cell-based ADME tests by utilization of the state-of-the-art techniques, industry leading products and equipment. We are dedicated to helping drug developers reduce cost and time-to-market by providing reliable and fast data. The service groups at Creative Bioarray are highly skilled in absorption, transport metabolism studies, which enable us to develop a wide range of ADME tests to meet the customers’ special needs.

 

Services

 

Identifying the interactions between candidate compounds and transporters is an important step in the development of drugs. Drug transporters, functioning as uptake or efflux pumps, are widely expressed in many tissues including intestinal enterocytes, hepatocytes, kidney proximal tubules, blood-brain barrier capillary endothelial cells. Drug-transporter interaction influences not only the bioavailability but also interactions between different drugs.  Creative Bioarray has extensive expertise in determining whether a test compound act as a substrate or inhibitor of various transporters.

The transporters we test include but not limited to:

☆ P-gp (P-glycoprotein, or MDR1)
☆ BCRP (Breast Cancer Resistance Protein)
☆ MRP2 (Multi-Drug Resistance Protein 2)

To this end, bi-directional transport assays are conducted by Creative Bioarray using Caco-2 or MDR1-MDCK cells. Other cell lines are also available according to your specifications.

Technical Support & Price Inquiry

Please input "bioarray" as verification code.

Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com