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Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. Read more >
Despite improved clinical outcomes seen following antiretroviral therapy (ART), resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV-1). However, such cells are not likely the solitary viral reservoir and as such defining where and how others harbor virus is imperative for eradication measures. Read more >
Extramedullary plasmacytoma (EMP) a rare plasma cell disorder and is frequently associated with plasma cell bone marrow infiltration. Most EMPs involve mucosal lymphoid tissue, especially in the nasopharyngeal area, respiratory tract, and head and neck region. Primary involvement of the kidney is exceedingly rare.
MS4A4A is a member of the membrane-spanning, 4 domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcRβ (MS4A2) and Htm4 (MS4A3). Like the first three members of this family, transcription of MS4A4A appears to be limited to hematopoietic cells. To evaluate expression of the MS4A4A protein in hematopoietic cell lineages and subsets we generated monoclonal antibodies against extracellular epitopes for use in flow cytometry. Read more >
Older acute myeloid leukemia (AML) patients have a poor prognosis, therefore novel therapies are needed. Allogeneic natural killer (NK) cells have been adoptively transferred with promising clinical results. Here, we report the first-in-human study exploiting an unique scalable NK cell product generated ex vivo from CD34+ hematopoietic stem and progenitor cells (HSPCs) from partially HLA-matched umbilical cord blood units. Read more >
Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. Read more >
Plasma cells in human bone marrow (BM) are thought to be responsible for sustaining lifelong immunity, but its underlying basis is controversial. Here we use high-throughput sequence analysis of the same individual across 6.5 years to show that the BM plasma cell immunoglobulin heavy chain repertoire is remarkably stable over time. Read more >
Vitamin D-binding protein (DBP) is a highly expressed plasma protein with many important functions, including transport of vitamin D metabolites, sequestration of actin, control of bone metabolism and modulation of immune and inflammatory responses. Previous results of our study indicated an association between DBP and periodontitis. Read more >
|Cat#||Product Name||Description||Recommended Medium||Price|
|CSC-6249W||CM-S/Tum||Species: human; Tissue: bone marrow||Culture conditions: RPMI-1640 + 10% FBS; spli...||INQUIRY|
|CSC-6310W||ROV-S||Species: human, Caucasian; Tissue: bone marro...||RPMI-1640 + 20%FCS + 5ng/ml GM-CSF + 2mML-Glu...||INQUIRY|
|CSC-7869W||Human Bone Marrow Stromal Cells (Postnatal)||Human bone marrow stromal cells or mesenchyma...||-----||INQUIRY|
|CSC-C2844||Human Bone Marrow Mononuclear Cells||Human bone marrow mononuclear cells are isola...||-----||INQUIRY|
|CSC-C4395X||Waldenstrom's Macroglobunemia Bone Marrow Mononuclear Cells - Untreated||Waldenstrom's Macroglobunemia-Bone Marrow-Mon...||-----||INQUIRY|
|CSC-C4446X||Myelodysplastic Syndrome Bone Marrow Mononuclear Cells (Relapsed/Refractory)||Bone Marrow is obtained from adult Myelodyspl...||-----||INQUIRY|
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