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ActoFactor™ Recombinant Mouse Intercellular adhesion molecule 1

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0036
  • Description
  • Mouse soluble ICAM-1 is a recombinant protein derived from the cell adhesion molecule ICAM-1 (CD54). ICAM-1 has a molecular =mass of approximately 95 kDa. It is a membrane protein expressed on many cell types and its expression is upregulated upon cell activation. It binds to two integrins on leukocytes, namely LFA-1 and Mac-1. Cell adhesion mediated by these molecules is critical for a wide range of cellular interactions in the immune system, including leukocyte adhesion to endothelial cells and interaction between T cells and antigen-presenting cells. The adhesion of leukocytes to ICAM-1 requires functional activation of LFA-1 or Mac-1 on leukocytes. Purified sICAM-1 adsorbed to a solid support binds activated cells expressing LFA-1 or Mac-1, but not resting cells. This binding can be blocked by the monoclonal anti-ICAM-1 antibody (in mouse with clone YN1/1; Catalog #01503), anti-LFA-1 or anti-Mac-1, indicating a direct interaction of these molecules in cell adhesion. Soluble ICAM is useful for the studies of the activation of leukocyte adhesion in immune responses and inflammatory reactions.
  • Species
  • Mouse
  • Product Overview
  • Mouse Icam1 expressed in NS-1
  • Sequence
  • Soluble ICAM-1 is produced in NS-1 cells.
  • Size
  • CAT# CSC-CTK0036-100 (100 μg); CAT# CSC-CTK0036-500 (500 μg)
  • Expression System
  • NS-1
  • Purity
  • Please refer to PIS (Product Information Sheet)
  • Storage & Stability
  • Product stable at -20°C (-25°C to -15°C) until expiry date indicated on label. Avoid repeated freezing and thawing.

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      Tel: 1-631-626-9181
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      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com