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ActoFactor™ Recombinant Human Tumor necrosis factor receptor superfamily, member 1B

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0358
  • Description
  • TNFR2 is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-alpha but manifests a lower affinity to TNF-beta. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFR2 is capable of inhibiting TNF-alpha induced activities by acting as a decoy receptor. Recombinant human sTNFR2 is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.
  • Species
  • Human
  • Product Overview
  • Human TNFRSF1B expressed in E.coli
  • Molecular Mass
  • 18.9 kDa
  • Size
  • CAT# CSC-CTK0358-20 (20 μg); CAT# CSC-CTK0358-100 (100 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 97% as determined by SDS-PAGE and HPLC analysis.
  • Activity
  • Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha is 0.125 μg/ml.
  • Endotoxin Level
  • Less than 1 EU/μg.
  • Formulation
  • lyophilized from a sterile-filtered solution in 10 mM Sodium Phosphate, pH 8.0 + 50 mM NaCl.
  • Reconstitution
  • Please centrifuge product before opening vial. The lyophilized TNFR2 should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu sTNFR2 should be used immediately or stored long-term in undiluted working aliquots at -20°C.

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If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.

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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com