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ActoFactor™ Recombinant Human Tumor necrosis factor receptor superfamily, member 11b

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0354
  • Description
  • Recombinant Human Osteoprotegerin (rHu OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. Recombinant human OPG (OPG-Fc) produced in yeast has a calculated molecular mass of 46.5 kDa and contains 412 amino acid residues, including 180 residues from mature OPG (aa 22-201) and 232 residues from the Fc protein of human IgG1.
  • Species
  • Human
  • Product Overview
  • Human TNFRSF11B expressed in P. pastoris
  • Molecular Mass
  • ~47 kDa
  • Size
  • CAT# CSC-CTK0354-50 (50 μg); CAT# CSC-CTK0354-250 (250 μg)
  • Expression System
  • P. pastoris
  • Purity
  • Greater than 90% as determined by SDS-PAGE and HPLC analysis.
  • Activity
  • Biological activity was determined the abilty of OPG to neutralize the stimulation of U937 cells treated with 10 ng/ml of sRANKL.
  • Endotoxin Level
  • N/A
  • Formulation
  • Lyophilized from a sterile-filtered protein solution (0.5 mg/ml) in PBS (pH 7.4).
  • Reconstitution
  • Please centrifuge product briefly before opening the vial. The lyophilized protein should be reconstituted in 5 mM Tris (pH 7.5) to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • The lyophilized rHu OPG, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu OPG should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.

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    • USA
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      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
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      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com