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ActoFactor™ Recombinant Human Matrix Metalloproteinase 8

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0372
  • Description
  • Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. Human recombinant Matrix Metalloproteinase-8 produced in E. coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa.
  • Species
  • Human
  • Product Overview
  • Human MMP8 expressed in E.coli
  • Molecular Mass
  • 75 kDa
  • Size
  • CAT# CSC-CTK0372-10 (1 unit); CAT# CSC-CTK0372-50 (5 unit)
  • Expression System
  • E.coli
  • Purity
  • Greater than 90% as determined by SDS-PAGE analysis.
  • Activity
  • 100 units/ml after activation with APMA by solution assay method. One unit of collagenolytic activity is defined as the cleavage of 1 μg of collagen per minute by the solution method.
  • Endotoxin Level
  • N/A
  • Formulation
  • Sterile-filtered, clear solution (100 units/ml) in 0.05 M Tris-HCl buffer (pH 7.6), containing 0.2 M NaCl, 5 mM CaCl ? , 0.0025% NaN ? and 0.1% BSA.
  • Reconstitution
  • Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • Store at 4°C if entire vial will be used within 1 week. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

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      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
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      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com