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ActoFactor™ Recombinant Human LIN-28

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0604
  • Description
  • LIN-28 plays an important role as a translational enhancer, leading specific mRNAs to polysomes and therefore increasing the competence of protein synthesis. LIN-28 is a marker of undifferentiated human embryonic stem cells and it enhances the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. LIN-28 binds to the let-7 pre-miRNA and blocks production of the mature let-7 microRNA in mouse embryonic stem cells. Overexpression of LIN-28 is associated with human germ-cell tumors. Human recombinant LIN-28 produced in E. coli is a single, non-glycosylated polypeptide chain of 191 amino acids (42-209) and a molecular mass of 21.1 kDa. LIN-28 is expressed with a 23 amino acid His-tag fused at the N-Terminus and purified by proprietary chromatographic techniques.
  • Species
  • Human
  • Product Overview
  • Human LIN28A expressed in E.coli
  • Molecular Mass
  • 21.1 kDa
  • Size
  • CAT# CSC-CTK0604-10 (10 μg); CAT# CSC-CTK0604-50 (50 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 90% as determined by SDS-PAGE analysis.
  • Activity
  • N/A
  • Endotoxin Level
  • Less than 1 EU/μg.
  • Formulation
  • Sterile filtered, colorless solution containing 20 mM Tris-HCl (pH 8.0), 10% glycerol and 0.1 M NaCl.
  • Reconstitution
  • Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

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      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
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      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com