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ActoFactor™ Recombinant Human Interleukin 2 receptor, alpha
- Specification
- Recommended Products
Cat.No.
CSC-CTK0303
Description
The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R alpha, IL- 2R beta, and IL-2R gamma. The IL-2R alpha is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R alpha releases the entire extracellular domain of IL-2R alpha thereby generating a 219 a.a. soluble protein called soluble IL-2R alpha (sIL-2R alpha). The homodimeric form binds IL-2 (KD=10 mM) and facilitates IL-2 signaling. The secreted sIL-2R alpha is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R alpha produced in E. coli is a single, non-glycosylated polypeptide chain of 192 a.a. residues (22-213) corresponding to the mature IL-2R protein with an amino- terminal 6xHis tag.
Species
Human
Product Overview
Human IL2RA expressed in E.coli
Molecular Mass
N/A
Size
CAT# CSC-CTK0303-25 (25 μg); CAT# CSC-CTK0303-125 (125 μg)
Expression System
E.coli
Purity
Greater than 95% as determined by SDS-PAGE and HPLC analyses.
Activity
N/A
Endotoxin Level
N/A
Formulation
Sterile, colorless liquid formulation (184 μl; 136 μg/ml). Supplied in 1XPBS, 50% glycerol (pH 7.4).
Reconstitution
Please centrifuge product briefly before opening the vial. The rHu CD25 can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
Store at 4°C if the entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid repeated freeze-thaw cycles..
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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