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Stem cell therapy is a promising therapeutic option to treat patients after myocardial infarction. However, the intramyocardial administration of large amounts of stem cells might generate a proarrhythmic substrate. Proarrhythmic effects can be explained by electrotonic and/or paracrine mechanisms. The narrow therapeutic time window for cell therapy and the presence of comorbidities limit the application of autologous cell therapy. Read more >
Biopsy specimens of the thymus were studied in children aged under 11 months (n = 77) with congenital heart defects and circulatory hypoxia of varying severity. Histological sections were stained with hematoxylin-eosin and Shubichs method (to demonstrate mast cells). The expression of Ki-67, CD3 and CD34 was assessed by immunohistochemistry. Read more >
Engineered 3D cardiac tissue constructs (ECTCs) can replicate complex cardiac physiology under normal and pathological conditions. Currently, most measurements of ECTC contractility are either made isometrically, with fixed length and without control of the applied force, or auxotonically against a variable force, with the length changing during the contraction. Read more >
Ischaemic heart disease is the predominant contributor to cardiovascular morbidity and mortality; one million myocardial Infarctions occur per year in the USA, while more than five million patients suffer from chronic heart failure. Recently, heart failure has been singled out as an epidemic and is a staggering clinical and public health problem associated with significant mortality, morbidity and healthcare expenditures, particularly among those aged ≥65 years. Read more >
Stimulation of the renin-angiotensin-aldosterone system (RAAS) and β-adrenergic receptors plays an important role in adult heart failure (HF). Despite the demonstrated benefits of RAAS inhibition and β-adrenergic receptor blockade in adult HF patients, no substantial improvement in survival rate has been observed in children with HF. Read more >
T-box 18 (TBX18) plays a crucial role in the formation and development of the head of the sinoatrial node. The objective of this study was to induce adipose-derived stem cells (ADSCs) to produce pacemaker-like cells by transfection with the TBX18 gene. A recombinant adenovirus vector carrying the human TBX18 gene was constructed to transfect ADSCs. Read more >
We have developed an engineered heart tissue (EHT) system that uses laser-cut sheets of decellularized myocardium as scaffolds. This material enables formation of thin muscle strips whose biomechanical characteristics are easily measured and manipulated. To create EHTs, sections of porcine myocardium were laser-cut into ribbon-like shapes, decellularized, and mounted in specialized clips for seeding and culture. Read more >
|Cat#||Product Name||Description||Recommended Medium||Price|
|CSC-7686W||adult stem cells||Bioarray, a pioneer in the adult stem cell fi...||-----||INQUIRY|
|CSC-7695W||Human Vertebral Mesenchymal Stem Cells (HVMSC)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
|CSC-7700W||Human Umbilical Mesenchymal Stem Cells (HUMSC)||Mesenchymal stem cells (MSC) are a well-chara...||-----||INQUIRY|
|CSC-7725W||Human Pulmonary Mesenchymal Stem Cells (HPMSC)||Mesenchymal stem cells (MSC) are a well-chara...||-----||INQUIRY|
|CSC-7755W||Human Mesenchymal Stem Cells-hepatic (HMSC-he)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
|CSC-7756W||Human Mesenchymal Stem Cells-bone marrow (HMSC-bm)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
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